Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot
study
T. Shestakova1, E. Zhuravel1, L. Bolgova2, O.
Alekseenko2, M. Soldatkina1, P. Pogrebnoy1, *
1R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS
of Ukraine, Kyiv, Ukraine 2State Institution “National Cancer Institute”, Ministry of Health of
Ukraine, Kiev, Ukraine
Abstract. To analyze the patterns of human beta-defensin-1, 2, 4 (hBDs) expression in human
lung tumors. Materials and Methods: Tissue samples of surgically resected human lung
tumors (squamous cell carcinoma (SCC), n = 10; adenocarcinoma (AC), n = 10) paired
with conditionally normal tissue samples were analized for expression of hBD-1, 2, 4 mRNA
by semiquantitive RT-PCR. Results: In a number of studied lung cancer tissue samples,
overexpression of defensin mRNA was registered: hBD-1 mRNA (50% of SCC and 60% AC), hBD-2
mRNA (60% of SCC and 50% of AC) or hBD-4 (40% of SCC and 20% AC). No correlation was
detected between the levels of hBD-1, hBD-2 and hBD-4 mRNA and histological type,
differentiation grade of the tumor, and the stage of the disease, as well as the content
of hBD-2 peptide in blood serum of lung cancer patients. Conclusion: Human
beta-defensins-1 and -2 are often up-regulated in human lung tumors.
Key Words:human beta-defensin, human lung tumors, expression.
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