Vol. 30, No. 2, 2008 (June)
	Content

L-myc gene polymorphism and risk of thyroid cancer

I. Yaylim-Eraltan¹, N. Bozkurt¹, A. Ergen¹, U. Zeybek¹,
O. Ozturk¹, S. Arikan², Y. Erbil³, I. Uslu⁴, H. Camlica⁵, T. Isbir^1, *

¹Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
²Istanbul Research and Education Hospital, Surgery Clinic, Istanbul, Turkey
³Istanbul University, Istanbul Medical Faculty, Department of General Surgery, Istanbul, Turkey
⁴Istanbul University, Cerrahpasa Medical Faculty, Department of Nuclear Medicine, Istanbul, Turkey
⁵Istanbul University, Institute of Oncology, Division of Cancer Epidemiology and Biostatistics, Istanbul, Turkey

Abstract. L-myc gene polymorphism is a representative genetic trait responsible for an individual’s susceptibility to several cancers. However, there have been no reports concerning the association between thyroid cancer and L-myc gene polymorphism. Aim: To analyze the distribution of L-myc gene polymorphism in Turkish patients with thyroid disorders and thyroid cancers. Methods: We used a molecular genotyping method, polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). We studied 138 patients of whom 47 had multinodular goiter, 13 had follicular cancer and 69 had papillar cancer, in comparison with control group of 109 healthy individuals. Results: No significant difference in the distribution of genotypes was observed between thyroid patients and controls. Carrying SS or LS genotype revealed a 1.96-fold (95% CI 0.573–6.706) risk for the occurrence of follicular cancer when compared with controls, and 3.11-fold (95% CI 0.952–10.216), when compared with multinodular goiter patients (p = 0.04). Conclusion: We suggest that L-myc genotype profiling together with other susceptibility factors, may be useful in the screening for thyroid nodular malignancy.

Key Words: allele, cancer, L-myc, polymorphism, thyroid gland.

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