Vol. 30, No. 2, 2008 (June)
	Content

Genes controlling spread of breast cancer to lung “gang of 4”

S.A. Eltarhouny^{1, 2}, W.H. Elsawy³, R. Radpour¹, S. Hahn¹, W. Holzgreve¹, X.Y. Zhong^1, *

¹Laboratory for Prenatal Medicine and Gynaecologic Oncology, Department of Biomedicine, Women’s Hospital, University of Basel, Switzerland
²Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Egypt
³Clinical Oncology Department, Faculty of Medicine, Zagazig University, Egypt

Abstract. Cancer-related mortality is caused in a large part by the metastasis of primary tumor. Each cancer has a particular way of spreading cancerous cells. Recently, genetic and pharmacological analysis identified the set of genes, such as epidermal growth factor receptor ligand epiregulin (EREG), cyclooxygenase-2 (COX2) and matrix metalloproteinases 1 and 2 (MMP-1 and MMP-2) that have been found to be associated with metastasis of breast cancer to lung. Inhibition of EGFR and COX2 could minimize lung metastasis of breast cancer in a clinical setting. In this review, we summarized the current knowledge on EREG, COX2, MMP-1 and MMP-2 in tumor development and metastasis.

Key Words: breast cancer, EPREG, COX2, MMPs, metastasis.

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