WHOLE BODY HYPERTHERMIA SUPPLEMENTED WITH UROTROPIN IN THE TREATMENT OF MALIGNANT TUMORS
Reiman S. Ismail-zade
Oncology Department, Belarusian Center for Pediatric Oncology and Hematology, P.O. Lesnoy, Minsk 223040, Belarus
Abstract. Aim: To evaluate the effect of urotropin on the tolerance of an extreme whole body hyperthermia (WBH) regime (44.5–45.0 °С for 60 min) in rats,
and then its application to pediatric patients with advanced cancer during WBH sessions (42.5–43.0 °С). Methods: In experiments nonbred rats
bearing Sarcoma 45 (Sa 45) were subjected to severe WBH with and without urotropin. Tolerance of WBH as well as tumor growth and survival of animals
were monitored. Extreme WBH sessions (42.5–43.0 °С) + urotropin were used in multimodal treatment of 13 children with advanced, refractory or recurrent
malignant tumors (42 procedures in total). Results: Our experiments showed 5-fold increase in rat survival during the first two days following application
of extreme WBH due to the additional administration of urotropin. This regime demonstrated a significant inhibitory effect upon the growth of Sa 45. In children
with progressive malignant tumors we achieved extreme WBH regimes (up to 43.2 °С) using urotropin without additional toxicity and with 69% overall response
rate. Conclusion: Extreme WBH (42.5–43.0 °С) could be used in the management of advanced and refractory cancer. Urotropin may play a favorable
role during the procedures of extreme WBH, decreasing thermal damage to the body. Lymphocyte collection by lymphopheresis before WBH session and
its reinfusion may be one of the progressive approaches for minimizing lymphocyte apoptosis.
Key Words:extreme WBH, Sarcoma 45, urotropin, cancer in children.
