Vol. 26, No. 2, 2004 (June)
	Content

ANALYSIS OF MALIGNANCY-ASSOCIATED DNA CHANGES IN INTERPHASE NUCLEI OF BUCCAL EPITHELIUM IN PERSONS WITH BREAST DISEASES

Natalya Boroday¹, Dmitriy Klyushin², Yuriy Petunin², Roman Andrushkiw³

¹R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine
²Kyiv National Shevchenko University, Kyiv 01022, Ukraine
³Department of Mathematical Sciences and Center for Applied Mathematics and Statistics, New Jersey Institute of Technology, Newark, NJ 07102

Abstract. Aim: To study from the point of view of statistical and geometrical theory of pattern recognition, the peculiarities of the distribution of optical density of DNA in the interphase nuclei of mammary buccal epithelium upon pathology. Methods: Cytogenetic investigation of buccal smears and computer-based image analysis were used. Results: It is shown that in malignant neoplasms of the mammary glands compared with its values in benign, the optical density of DNA in the nuclei of buccal epithelium increase in a range from 0.15 to 0.30 conventional units. The sensitivity of that criterium varied from 80.5% to 96.8%, and specificity was 92.3%. Conclusion: The method proposed may be recommended as an additional one for improvement of the diagnosis of mammary pathologies.

Key Words: breast cancer, malignancy-associated changes, buccal epithelium, confidence interval, pattern recognition.

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