Vol. 26, No. 1, 2004 (March)
	Content

ENHANCEMENT OF ANTITUMOR RESPONSE TO SARCOMA 45 IN RATS BY COMBINATION OF WHOLE-BODY HYPERTHERMIA AND INTERLEUKIN-2

Michael P. Potapnev^1,*, Yuri P. Istomin², Reiman S. Ismail-zade¹, Edvard A. Zhavrid²

¹Research Department, Belarussian Research Center for Pediatric Oncology & Hematology, P.O. Lesnoy, Minsk BE-223052, Belarus
²N.N. Alexandrov Research Institute of Oncology & Medical Radiology, P.O. Lesnoy-2, 223040 Minsk, Belarus

Abstract. Aim: To evaluate the summarized effect of hyperthermia and interleukin-2 (IL-2) administration on antitumor defense in tumor-bearing rats. Methods: Nonbred rats after subcutaneous inoculation of sarcoma 45 cells were treated with whole-body hyperthermia (WBH, +42.5 ^оС, 60 min) and interleukin-2 (IL-2, 10 000 U/kg of body weight). Parameters of tumor growth and survival of animals were monitored till day 33 after tumor cell inoculation. Results: Combined application of WBH and IL-2 at 5th day after tumor cell transplantation resulted in a delay of tumor growth and improvement of survival parameters in comparison with control group or animals that received separate treatment. Therapeutic efficacy of WBH combined with IL-2 was analogous to a single-dose chemotherapy with cyclophosphamide. Conclusion: Combined application of WBH and IL-2 is the useful approach for cancer immunotherapy.

Key Words: hyperthermia, interleukin-2, sarcoma 45, rats.

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