State Institute "N.N. Alexandrov Research Institute of Oncology and Medical Radiology", Minsk, Belarus
Abstract. Aim: To evaluate oxidative metabolism of rat blood in the course of alveolar hepatic cancer growth in vivo.Methods: The oxidation imbalance was assessed by the rise in the values of the integral index of oxidation stress. The structural and functional state of erythrocyte membranes was investigated by spin electron paramagnetic resonance spectroscopy. Results: The growth of alveolar carcinoma was found to be associated with intensification of lipid peroxidation processes with increased blood content of conjugated dienes, malonic dialdehyde against the background of decreased concentration of endogenous antioxidants tocopherol and retinol. Destabilization of the structural state of erythrocyte membranes of rat tumor hosts at the development of oxidation stress was studied, which was characterized by nonspecific structural changes of membrane sorption centres, reduction in specific capacity in the protein–lipid contact area and its increase in the phospholipid bilayer, rise in the degree of order and polarity. Conclusion: Alveolar carcinoma growth in rats resulted in intensification of free radical lipid peroxidation processes with a shift of the prooxidant–antioxidant balance to the left and development of oxidation stress.
Key Words:oxidative metabolism, alveolar carcinoma, rat, homeostasis, membrane.
