Vol. 25, No. 2, 2003 (June)
	Content

EXPRESSION OF p70S6 KINASE IN GUERIN’S CARCINOMA CELLS UPON TUMOR DEVELOPMENT

D.I. Lytvyn¹, T.N. Dudchenko¹, V.V. Filonenko², L.A. Savinskaya², P.V. Pogrebnoy¹

¹R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine
²Institute of Molecular Biology and Genetics NAS of Ukraine, Kyiv, Ukraine

Abstract. Alteration of expression levels of p70S6 kinase (p70S6K) in Guerin’s carcinoma cells in vivo upon dynamics of tumor development has been studied. The expression levels of p70S6K were studied by Western blot analysis with the use of polyclonal anti-p70S6K-antibodies in the samples of tumor tissues, uteral tissues of tumor-bearing animals (control) and uteral tissues of healthy animals (negative control). The data have demonstrated that in tumor tissues the level of p70S6K expression is higher than in normal uteral tissue, and that development of Guerin’s carcinoma is accompanied by increase of p70S6K expression on the initial stages and by its decrease on the terminal stages.

Key Words: p70S6 kinase, Guerin’s carcinoma.

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