Vol. 25, No. 2, 2003 (June)
	Content

OPPOSITE EFFECTS OF bFGF AND TGF-b1 ON TGF-b1 mRNA EXPRESSION IN HUMAN MCF-7 BREAST CARCINOMA CELLS

R.S. Stoika

Institute of Cell Biology, NAS of Ukraine, Lviv 79005, Ukraine

Abstract. Transforming growth factor b₁ (TGF-b₁) is known as a growth inhibitor for most normal and transformed epithelial cells whilst basic fibroblast growth factor (bFGF) is a mitogenic agent. Here we show that TGF-b₁ mRNA expression is inhibited under the action of TGF-b₁ and induced under the action of bFGF in human breast carcinoma cells of MCF-7 line. mRNA expression of human pituitary tumor transforming gene was not changed under the action of these cytokines.

Key Words: transforming growth factor b₁, basic fibroblast growth factor, mRNA, pituitary tumor transforming gene, human breast carcinoma cells MCF-7 line, growth inhibition.

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