Vol. 25, No. 2, 2003 (June)
	Content

INHIBITION OF TUMOR DEVELOPMENT BY CYTOPLASMIC MEMBRANES OF PROTEUS MIRABILIS STABLE L-FORM

R. Toshkova¹, E. Ivanova², S. Toshkov³, C. Hoischen⁴

¹Institute of Experimental Pathology and Parasitology, Sofia, Bulgaria
²Institute of Microbiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
³National Center of Haematology and Transfusiology, Sofia 1756, Bulgaria
⁴Institute of Molecular Biotechnology, Jena-D-07745, Germany

Abstract. In the present work the effect of Proteus mirabilis VI stable L-form cytoplasmic membranes (CMPm) on the survival and tumor growth in hamsters with transplanted myeloid Graffi tumors was studied. Single doses of 0.25 mg or 0.5 mg CMPm were injected i.p. 1 week before tumor transplantation. Such treatment induced elongation of the latent time of tumor appearance, inhibition of tumor growth and enhancement of the mean survival time of experimental animals. The oncoprotective effect could be due to the preliminary established immunostimulating activity of the preparation.

Key Words: bacterial L-forms, transplanted tumor, cytoplasmic membranes, Proteus mirabilis.

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