Vol. 25, No. 2, 2003 (June)
	Content

ANTICANCER AND IMMUNOSTIMULATORY EFFECTS OF NUCLEOPROTEIN FRACTION OF BACILLUS SUBTILIS 7025 CULTURE MEDIUM FILTRATE

V.А. Shlyakhovenko¹, S.V. Olishevsky¹, V.V. Kozak¹, Y.V. Yanish¹, S.L. Rybalko²

¹R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv 03022, Ukraine
²V.L. Gromashevsky Research Institute of Epidemiology and Infectious Diseases, Medical Academy of Sciences of Ukraine, Kyiv, Ukraine

Abstract. Antitumor and immunostimulatory effects of nucleoprotein fraction of Bacillus subtilis 7025 (NPF) cultural medium filtrate have been investigated. Although a number of important questions remains to be answered our experiments indicated that NPF of Bacillus subtilis 7025 cultural medium filtrate can be effective as antitumor immunotherapeutic agent, has significant immunostimulatory effects and augments NK cell cytotoxicity and IFN-a/g-producing activity of leukocytes.

Key Words: antitumor autovaccine, Bacillus subtilis 7025, bacterial DNA, CpG DNA, glycopeptide, interferons, NK cells, murine Erlich’s carcinoma, nucleoprotein fraction, vesicular stomatitis virus.

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