Vol. 25, No. 2, 2003 (June)
	Content

IMMUNOSTIMULATORY CpG DNA IN CANCER VACCINOTHERAPY

S.V. Olishevsky, V.V. Kozak, Y.V. Yanish, V.А. Shlyakhovenko

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv 03022, Ukraine

Abstract. In the review, recent data on the application of CpG DNA in immunotherapy and cancer vaccinotherapy are presented. Preliminary studies confirmed that administration of CpG DNA alone or in combination with other agents may be effective in a variety of cases and that CpG DNA may be used as a potent immune adjuvant. Some possible molecular mechanisms responsible for the immunostimulatory effects of CpG DNA are discussed.

Key Words: CpG oligodeoxynucleotides, CpG-S DNA, B-cells, dendritic cells, T-cells, lymphocyte activation, Toll-like receptor, vaccine, immunomodulator, adjuvant, immunotherapy, tumor, cancer therapy.

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