EFFECT OF HELIUM-NEON LASER IRRADIATION ON ANTITUMOR ACTIVITY OF LAK AND IL-2 IN MICE WITH LEWIS LUNG CARCINOMA
N.F. Gamaleya*, L.M. Skivka, A.G. Fedorchuk
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, Kyiv, Ukraine
Abstract. The effect of combined treatment by laser irradiation, adoptive immunotherapy with lymphokin-activated killer cells (LAK) and interleukin-2 (IL-2) on tumor growth and metastasis in vivo has been evaluated. It has been shown that the laser exposure of LAK in vitro just before adoptive transfer improves antitumor effect of treatment, especially at a stage of metastasis. Laser irradiation of murine blood in vivo carried out simultaneously with adoptive immunotherapy and IL-2 treatment had no positive results.
