1A.N. Sysin SU SRI of Human Ecology and Hygiene of Environment of RAMS, Moskow, Russia 2Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of RAS, Moskow, Russia 3N.N. Petrov SU RSI of Oncology of MH of Russian Federation, St-Petersburg, Russia
Abstract. Olypiphate (OP) is a new preparation received from lignin by multistage technology and containing guimine compounds. Preparation has been tested for different biological activities in vivo (in particular, for antitumor activity) and has been recommended for clinical trials in cancer patients. That’s why remote effects of OP action has been investigated, i.e. the study of OP influence on generative function in rat, its embryotoxic action in antenatal and postnatal periods, potential mutagenecity by Aims test and ability to induce chromosomal aberrations as well as the testing of OP potential cancerogeneity on Danio rerio fish. It was revealed that OP doesn’t cause remote consequences.
