1P.L. Shupik Kyiv Medical Academy of Postgraduate Education, Ministry of Health of Ukraine, Kyiv, Ukraine 2R.Е. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine 3Institute of Hematology and Transfusiology, AMS of Ukraine, Kyiv, Ukraine
Abstract. The research of the metastatic level in mice with pulmonary carcinoma (3LL) upon administration of inhibitors of the haemostasis after resection of primary tumor is carried out. In the groups of animals different preparations were introduced: 1) heparin (during 6 days after surgery); 2) calcium nadroparin (CN) (before operation and during 6 days after it); 3) CN as in group 2 + ticlopidine during 7-th–21-th days. For monitoring of the levels of tumor dissemination the volumes of pulmonary metastasis (VPM) and level of the VEGF were determined. For evaluation of platelet activity level, the level of platelet aggregation, induced by arachidonic acid (PAIAA) was used. It has been shown that the application of antihaemostatic preparations contributes to the decrease in the level of tumor dissemination especially if CN in combination with ticlopidine are applied. Also, the slowing of metastasis was shown to correlate with inhibition of platelet aggregating function upon introduction of antiaggregants.
