1R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine 2Institute of Oncology, Academy of Medical Sciences of Ukraine, Kyiv 03022, Ukraine
Abstract. According to the data of 1Í NMR-spectroscopy the chemical structure of mechanochemically modified doxorubicin (MCM-DR) remains unaltered but is characterized by increased time constant of a spin-spin relaxation (T2). In MCM-DR solution the increase of concentration of monovalent and divalent positively charged ions was registered. Whilst the chemotherapy with the use of officinal doxorubicin (OF-DR) had no effect in doxorubicin-resistant Guerin’s carcinoma, administration of OF-DR and total irradiation with frequency 40 MHz resulted in 22 ± 7% decrease of tumor volume on 19-th day after tumor inoculation. We showed also that total irradiation did not influence antitumor effect of MCM-DR; treatment with MCM-DR alone and in combination with irradiation results in 52 ± 4% decrease on the volume of doxorubicin-resistant Guerin’s carcinoma in comparison with control group and OF-DR-treated animals.
Key Words:doxorubicin-resistant Guerin’s carcinoma, mechanochemically modified doxorubicin, irradiation with frequency 40 MHz.
