Vol. 24, No. 3, 2002 (September)
	Content

PREVENTION BY PSEUDOMONAS PUTIDA OF THE BENZENE ACCUMULATION IN TUMOR AND NORMAL TISSUES (PILOT STUDY)

L. Campanella^1,, M.V. Russo²

¹Chemical Department, University “La Sapienza”, Rome 00185, Italy
²Agrarian Faculty (DiSTAAM), University del Molise, Campobasso 86100, Italy

Abstract. The ability of Pseudomonas putida to metabolize benzene accumulated in normal and tumor human tissues was tested in vitro. The metabolic degradation of benzene after incubation in vitro of normal and tumor tissues with benzene at 25 °C for 24 h was about 80 and 50% respectively, the rest of benzene has been accumulated. When incubation with benzene occurred in presence of P. putida the final metabolization value reached almost 100%. It was suggested that P. putida could be used as a potential treatment agent in the modulation of toxic states caused by benzene accumulation.

Key Words: benzene, Pseudomonas putida, human tissue, metabolic degradation, GC-MS.

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