LARGE GRANULAR LYMPHOCYTE LEUKEMIA IN CHERNOBYL CLEAN-UP WORKERS
D.F. Gluzman,I.V. Abramenko, V.M. Machilo
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv 03022, Ukraine
Abstract. 102 Chernobyl clean-up workers (1986–1987) with suspected hematooncological diseases were examined for precise diagnosis of leukemias and lymphomas. MDS and different types of hematopoieitic malignancies have been diagnosed in 57 patients. 3 cases of unusual chronic lymphoproliferative disorder —large granular lymphocyte leukemia (LGL-L) have been diagnosed for the first time within the group under study. Detailed cytomorhological and immunophenotypical characteristics of blood and bone marrow cells in LGL-L patients have been presented with particular emphasis on the possible relationship between chronic lymphoproliferative disorders and exposure to ionizing radiation.
