NON-MYELOABLATIVE STEM CELL TRANSPLANT USING 2-CHLORODEOXYADENOSINE (2-CDA) IN A PATIENT WITH MYELODYSPLASTIC SYNDROME (MDS)
T. Saito, S. Seo, R. Tanosaki, Y. Takaue, S. Mineishi
Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan
Abstract. Non-myeloablative conditioning regimens for allogeneic stem cell transplant have become popular recently. With non-myeloablative conditioning, regimen-related toxicities (RRT) are mild and engraftment of allogeneic graft can be achieved consistently. We performed non-myeloablative allogeneic peripheral blood stem cell transplant using 2-chlorodeoxyadenosine (Cladribine; 2-CdA), busulfan, and anti-thymocyte globulin (ATG) for a patient with myelodysplastic syndrome (MDS). He also had hemochromatosis in the liver due to blood transfusions. His post-transplant clinical course was uncomplicated. Non-myeloablative conditioning regimen containing 2-CdA facilitates engraftment with minimal toxicity.
