HEMATOLOGICAL DISORDERS INDUCED BY IRRADIATION IN HIROSHIMA AND CHERNOBYL: ANALYSIS OF MYELOPEROXIDASE-NEGATIVE ACUTE LEUKEMIAS BY FLOW CYTOMETRY AND POINT MUTATIONS OF p53 SUPPRESSOR ONCOGENE IN MYELODYSPLASTIC SYNDROME
N. Imamura
Department of Hematology and Oncology, Division of Clinical Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Abstract. The use of monoclonal antibodies for identification or characterization of heterogeneous acute unclassifiable leukemias (AULs) enables us not only to define these tumors of lymphoid, myeloid, and megakaryocytic cell origin but also to identify accurately the state of differentiation and their relationship to their normal counterparts, the lymphoid, myeloid, and megakaryocytic cells. In addition, accurate diagnosis should facilitate provision of effective therapies for AULs by means of various clinical applications.
