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Medline

PubMed, a service of the National Library of Medicine

World Oncology Network

R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology



Vol. 22, No. 1, 2000 (March)

Content

ONCOPROTEIN EXPRESSION PREDICTS RESPONSE TO RADIOTHERAPY OR THERMORADIOTHERAPY IN HUMAN CERVICAL CANCER

 

Y. Tanaka,Y. Harima

Department of Radiology, Kansai Medical University, Osaka, Japan

Abstract. The levels of Bax and Bcl-2 expression after 10.8 Gy radiotherapy are useful prognostic markers in patients with human cervical carcinoma. Thermoradiotherapy was found to result in better treatment responses than radiotherapy for patients with stage IIIB cervical carcinoma. An additive or synergistic antitumor effect of thermoradiotherapy is likely to occur through induction of apoptosis involving one of the bax pathways.

Key Words: cervical carcinoma, radiotherapy, thermoradiotherapy, Bax, Bcl-2, prognostic markers, apoptosis.

Language:  English

[full text]




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